I have a scheduled, nightly, full File & Folder backup of an internal data disk. Nothing else is stored on this disk except data. The destination is an external USB HD. Twice in the last few weeks the backup has failed automatic verification. The earlier backup failed with an error code 23. Last night's backup failed with error code 121. After the 1st failure, I ran a variety of Disk tools to check the health of the disk. All tests passed (chkdsk, Western Digital disk diagnostics, and Hard Disk Sentinel surface test). I have included the log from last night's failed verification.
EDIT: This external drive also stores a variety of disk images that are created nightly. None of them fail verification; only this F&F backup.
Backup ID - EA3453BF5148A6FA
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Backup Summary
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Backup Definition File: C:\Users\David\Documents\Reflect\7 Western Digital F&F (Disk 1-W) Daily.xml
Auto Verify: Y
Maximum File Size: Automatic
Compression: Medium
Password: N
NTFS Permissions: Y
Folder Reparse Points: Follow user reparse points, Do not follow system reparse points
Backup set matching: Similar - Match on backups with at least one matching folder
Shutdown: Forced
Email On Success: Y
Recipients: xxxx
Email On Warning: Y
Recipients: xxxx
Email On Failure: Y
Recipients: xxxx
Current Time: 9/14/2023 4:31:24 AM
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Destination
Backup Type: Full
File Name: W:\Reflect F&F (D) Daily\EA3453BF5148A6FA-00-00.mrbak
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Backup Sources
Folder: D:\Documents\
Include File Filter: *.*
Exclude File Filter: *.temp; *.tmp; *.bak; *.~*
Include Sub Folders: Y
Exclude Folder Filter:
Exclude Hidden Files: N
Exclude System Files: N
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Creating Volume Snapshot - Please Wait
Volume Snapshots Created
D:\ \\?\GLOBALROOT\Device\HarddiskVolumeShadowCopy3
Starting Backup - Thursday, September 14, 2023 4:31 AM
Write Method: Using Direct Disk I/O
Destination Drive: My Book (W

- Free Space 1.11 TB
Image Guardian: Protected
Free space threshold: Delete oldest backup sets when free space is less than 5.00 GB
Determining files to copy
Total Number of Files: 38715
Total Number of Folders: 3561
Total Size: 80.64 GB
Copying files
Saving cluster information
Saving Index
New File: 78.93 GB EA3453BF5148A6FA-00-00.mrbak
Verifying 'EA3453BF5148A6FA-00-00.mrbak'
Failed
Gathering Windows Events - Please Wait
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Email Notifications
Recipients: xxxx
Email notification sent
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Backup aborted! - 'EA3453BF5148A6FA-00-00.mrbak' Verification failed at 16% (Error reading 262153 bytes from file. Error code = 121)
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Macrium Reflect Home v8.1.7638 - 76-xxxx
Windows 10 Home (22H2) Build 19045.3570 (Desktop)
Windows 11 Home (22H2) Build 22621.1992 (Laptop)
Macrium Reflect 8.1.7771
Windows Defender