I want to make a image of my windows 10 drive. With Macrium 8 Home, I check the disk2 containing Windows. The four partitions are checked automatically. Under destination, folder option, I type osdisk2. [next] --->"Path Invalid"

How should I be selecting the destination?

The Destination needs to be entered as a standard Windows full folder path, such as D:\MyBackups. Alternatively, click the folder icon to the right of the Destination field to open a Browse dialog.